Professor Michael Arthur - publications

Nattrass M, Arthur MJP, Smythe P, McGill JI, Todd PG, Alberti KGMM.
Hyperlactataemia in diabetics with retinopathy during combined sulphonylurea and phenformin therapy.
Diabete et Metabolism, 1978;4:1 4.

Ashworth M, Arthur MJP, Turner AD, Smith PR.
A comparison of serum concentrations of sulphasalazine and some of its metabolites after therapy by the oral or rectal route.
Pharmatherapeutica, 1984;3:551 55.

Arthur MJP, Lee A, Wright R.
Sex differences in the metabolism of ethanol and acetaldehyde in normal subjects.
Clinical Science, 1984;67:397 401.

Arthur MJP, Tanner AR, Patel C, Wright R, Renwick AG, George CF.
Pharmacology of propranolol in patients with cirrhosis and portal hypertension.
Gut, 1985;26:14 19.

Hillier K, Smith CL, Jewell R, Arthur MJP, Ross G.
Abnormal duodenal mucosa synthesis of prostaglandins in duodenal ulcer disease.
Gut, 1985;26:237 240.

Arthur MJP, Bentley I, Kowalski Saunders P, Tanner AR, Millward Sadler GH, Wright R. Oxygen derived free radicals promote hepatic injury in the rat.
Gastroenterology, 1985;89:1114 1122.

Arthur MJP, Kowalski Saunders P, Wright R.
C parvum elicited hepatic macrophages demonstrate enhanced respiratory burst activity compared with resident Kupffer cells in the rat.
Gastroenterology, 1986;91:174 181.

Arthur MJP, Kowalski Saunders P, Gurney S, Tolcher R, Bull FG, Wright R.
Reduction of ferricytochrome C may underestimate superoxide production by monocytes.
Journal of Immunological Methods, 1987;98:63 69.

Arthur MJP, Kowalski Saunders P, Wright R.
Effect of endotoxin on release of reactive oxygen intermediates by rat hepatic macrophages.
Gastroenterology, 1988;95:1588 1594.

Shepherd HA, Royle G, Ross APR, Diba A, Arthur MJP, Colin Jones D.
Endoscopic biliary endoprosthesis in the palliation of malignant obstruction of the distal common bile duct: a randomized trial.
British Journal of Surgery, 1988;75:1166 1168.

Arthur MJP, Friedman SL, Roll FJ, Bissell DM.
Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen.
Journal of Clinical Investigation, 1989;84:1076 1085.

Friedman SL, Arthur MJP.
Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet derived growth factor receptors.
Journal of Clinical Investigation, 1989;84:1780 1785.

Iredale JP, Murphy G, Hembry RM, Friedman SL, Arthur MJP.
Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1 (TIMP-1): Implications for regulation of matrix degradation in liver.
Journal of Clinical Investigation, 1992;90:282-287.

Kowalski-Saunders P, Winwood PJ, Arthur MJP, Wright R.
Reversible inhibition of albumin production by rat hepatocytes maintained on a laminin-rich gel in response to secretory products of Kupffer cells and cytokines.
Hepatology, 1992;16:733-741.

Arthur MJP, Stanley A, Iredale JP, Rafferty JA, Hembry RM, Friedman SL.
Secretion of 72kDa type IV collagenase/gelatinase by cultured human lipocytes; analysis of gene expression, protein synthesis and proteinase activity.
Biochemical Journal, 1992;287(3):701-707.

Arany E, Afford S, Strain AJ, Winwood PJ, Arthur MJP, Hill DJ.
Differential cellular synthesis of insulin-like growth factor binding protein-1 (IGFBP-1) and IGFBP-2 messenger RNAs within human liver.
J Clin Endocrinol Metabol 1994;79:1871-1876.

Iredale JP, Goddard S, Murphy G, Benyon RC, Arthur MJP.
Tissue inhibitor of metalloproteinase-1 and interstitial collagenase expression in autoimmune chronic active hepatitis and activated human hepatic lipocytes.
Clinical Science, 1995;89:75-81.

Winwood PJ, Schuppan D, Iredale JP, Kawser CA, Docherty AJP, Arthur MJP.
Kupffer cell-derived 95kDa type IV collagenase/gelatinase B: Characterisation and expression in cultured cells.
Hepatology, 1995;22:304-315.

Vyas SK, Leyland H, Gentry J, Arthur MJP.
Transin (stromelysin) is expressed in early rat lipocyte primary culture.
Gastroenterology, 1995;109:889-898.

Benyon RC, Iredale JP, Goddard S, Winwood PJ, Arthur MJP. ­
Increased expression of tissue inhibitor of metalloproteinases-1 and -2 relative to interstitial collagenase in fibrotic human liver.
Gastroenterology 1996;110(3):821-831.

Aston KE, Stamouli A, Thomas EJ, Vyas SK, Iredale JP, Arthur MJP, Richardson MC.
Effect of gonadotrophin on cell and matrix retention and expression of metalloproteinases and their inhibitor in cultured human granulosa cells modelling corpus luteum function.
Molecular Human Reproduction 1996;2:26-30.

Herbert C, Arthur MJP, Robinson C.
Augmentation by eosinophils of gelatinase activity in the airway mucosa: comparative effects as a putative mediator of epithelial injury.
Br J Pharmacol 1996;117:667-674.

Iredale JP, Benyon RC, Arthur MJP, Ferris W, Alcolado R, Winwood P, Clark N, Murphy G.
TIMP-1 expression is enhanced relative to interstitial collagenase in experimental liver injury and fibrosis.
Hepatology 1996;24:176-184.

Leyland H, Gentry J, Arthur MJP, Benyon RC.
The plasminogen activating system in hepatic stellate cells.
Hepatology 1996;24:1172-1178.

Jenkins SA, Kingsnorth AN, Davies M, Elias E, Turnbull AJ Bassendine MF, James OFW, Iredale JP, Vyas S, Arthur MJP, Kendall F, Shields R.
A multicentre randomised controlled trial comparing the efficacy of Octreotide and injection sclerotherapy in the management of the acute variceal bleed.
Gut 1997;41:526-534.

Kawser CA, Iredale JP, Winwood PJ, Arthur MJP.
Rat hepatic stellate cell expression of alpha-2-macroglobulin is a feature of cellular activation (implications for matrix remodelling in hepatic fibrosis).
Clin Sci 1998;95:179-186.

Thomson RK, Davis Z, Palmer JM, Arthur MJP, Yeaman SJ, Chapman CJ, Spellerberg MB, Stevenson FK.
Immunogenetic analysis of a panel of monoclonal IgG and IgM anti-pyruvate dehydrogenase complex antibodies derived from patients with primary biliary cirrhosis.
J Hepatol 1998;28:582-594.

Iredale JP, Benyon RC, Pickering J, McCullen M, Northrop M, Pawley S, Hovell C, Arthur MJP.
Mechanisms of spontaneous resolution of rat liver fibrosis: Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors.
J Clin Invest 1998;102:538-549.

Thompson KC, Fowell A, Trowern A, Maneke M, Haycock C, Gentry J, Arthur MJP, Sheron N.
Primary rat and mouse hepatic stellate cells express the macrophage inhibitor cytokine interleukin 10 during the course of activation in vitro.
Hepatology 1998;28:1518-1524.

Bahr MJ, Vincent KJ, Arthur MJP, Fowler AV, Smart DE, Wright MC, Clark IM, Benyon RC, Iredale JP, Mann DA. Control of the tissue inhibitor of metalloproteinases-1 promoter in culture-activated rat hepatic stellate cells: regulation by activator protein-1 DNA binding proteins.
Hepatology 1999;29:839-848.

Gaca MDA, Pickering JA, Arthur MJP, Benyon RC. Human and rat hepatic stellate cells produce stem cell factor: a possible mechanism for mast cell recruitment in liver fibrosis.
J Hepatol 1999;39:850-858.

Elsharkawy AM, Wright MC, Hay RT, Arthur MJP, Hughes T, Bahr MJ, Degitz K, Mann DA.
Persistent activation of nuclear factor-KB in cultured rat hepatic stellate cells involves the induction of potentially novel rel-like factors and prolonged changes in the expression of I?B family proteins.
Hepatology 1999;30:761-769.

Benyon RC, Hovell CH, Gaca M, Jones E, Iredale JP, Arthur MJP.
Progelatinase A is produced and activated by rat hepatic stellate cells and promotes their proliferation.
Hepatology 1999;30:977-986.

Williams EJ, Gaca MDA, Brigstock DR, Arthur MJP, Benyon RC.
Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells.
J Hepatol 2000; 32: 754-761

 

Trim JE, Samra SK, Arthur MJP, Wright MC, McAulay M, Beri R, Mann DA.
Upstream tissue inhibitor of metalloproteinases-1 (TIMP-1) element-1, a novel and essential regulator DNA motif in the human TIMP-1 gene promoter, directly interacts with a 30-kDa nuclear protein.
J Biol Chem 2000;275(9):6657-6663.

Issa R, Williams E, Trim N, Kendall T, Arthur MJP, Reichen J, Benyon RC, Iredale JP.
Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factors.
Gut 2001;48(4):548-557.

Smart DE, Vincent KJ, Arthur MJP, Eickelberg O, Castellazzi M, Mann J, Mann DA.
JunD Regulates transcription of the tissue Inhibitor of Metalloproteinases-1 and Interleukin-6 Genes in Activated Stellate Cells.
J Biol Chem 2001;276(26):24414-24421.

Wright MC, Issa R, Smart DE, Trim N, Murray GI, Primrose JN, Arthur MJP, Iredale JP, Mann DA.
Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats.
Gastroenterology, 2001;121:685-698

Williams EJ, Benyon RC, Trim N, Hadwin R, Grove B, Arthur MJP, Unemori E, Iredale JP.
Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo.
Gut 2001; 49: 577-583

Vincent KJ, Jones E, Arthur MJP, Smart D, Trim J, Wright M, Mann DA.
Regulation of E-box DNA binding during in vivo and in vitro activation of rat and human hepatic stellate cells.
Gut 2001; 49: 713-719

Murphy FR, Issa R, Zhou X, Rhatnarajah S, Nagase H, Arthur MJ, Benyon C, Iredale JP
Inhibition of apoptosis of activated hepatic stellate cells by TIMP-1 is mediated via effects on MMP inhibition: Implications for reversibility of liver fibrosis.
J Biol Chem 2002; 277: 11069-76

Gao R, McCormick CJ, Arthur MJP, Ruddell R, Oakley F, Smart DE, Murphy FR, Harris MPG, Mann DA.
High efficiency gene transfer into cultured primary rat and human hepatic stellate cells using baculovirus vectors.
Liver:2002;22:15-22

Schiedermaier P, Harrison P, Arthur M, Grandt D, Sutton R, Drewe J, Larsen F, Sieber C; European Lanreotide Study Group.Effect of the somatostatin analogue lanreotide on meal-stimulated portal blood flow in patients with liver cirrhosis
Digestion. 2002;65(1):56-60.

Murphy F, Waung J, Collins J, Arthur MJ, Nagase H, Mann D, Benyon RC, Iredale JP.
N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1.
Comp Hepatol. 2004 Jan 14;3 Suppl 1:S8.

 

Bertrand-Philippe M, Ruddell RG, Arthur MJ, Thomas J, Mungalsingh N, Mann DA.
Regulation of Tissue Inhibitor of Metalloproteinase 1 Gene Transcription by RUNX1 and RUNX2
J Biol Chem. 2004 Jun 4;279(23):24530-9.

Reeves HL, Narla G, Ogunbiyi O, Haq AI, Katz A, Benzeno S, Hod E, Harpaz N, Goldberg S, Tal-Kremer S, Eng FJ, Arthur MJ, Martignetti JA, Friedman SL.
Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer.
Gastroenterology. 2004 Apr;126(4):1090-103.

Zhou X, Hovell CJ, Pawley S, Hutchings MI, Arthur MJP, Iredale JP, Benyon RC
Expression of matrix metalloproteinase-2 and -14 persists during early resolution of experimental liver fibrosis and might contribute to fibrolysis
Liver International, 2004; 24: 1-10

Takahara T., Smart DE., Arthur MJP., Oakley F., and Mann DA. MMP-9 gene transcription is induced in myofibroblasts cultured in 3-D collagen I gels: regulation by NF-kB, AP1 and Sp1.
Int J Biochem and Cell Biol 2004; 36: 353-63.

Issa R, Zhou X, Constandinou CM, Fallowfield J, Millward-Sadler H, Gaca MD, Sands E, Suliman I, Trim N, Knorr A, Arthur MJ, Benyon RC, Iredale JP. Spontaneous recovery from micronodular cirrhosis: evidence for incomplete resolution associated with matrix cross-linking.
Gastroenterology. 2004; 126(7):1795-808.

Rosenberg WM, Voelker M, Thiel R, Becka M, Burt A, Schuppan D, Hubscher S, Roskams T, Pinzani M, Arthur MJ; European Liver Fibrosis Group. Serum markers detect the presence of liver fibrosis: a cohort study.
Gastroenterology. 2004 Dec;127(6):1704-13.

Xu L, Hui AY, Albanis E, Arthur MJ, O'Byrne SM, Blaner WS, Mukherjee P, Friedman SL, Eng FJ. Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis.
Gut. 2005 Jan;54(1):142-51.

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