Leeds Institute of Genetics, Health and Therapeutics (LIGHT)

McKenna C; Walker S; Lorgelly P; Fenwick E; Burch J; Suekarran S; Bakhai A; Witte K; Harden M; Wright K; Woolacott N; Palmer S (2012) Cost-effectiveness of aldosterone antagonists for the treatment of post-myocardial infarction heart failure.. Value Health, 15 (3), pp. 420-428.

Mak S; Witte KK; Al-Hesayen A; Granton JJ; Parker JD (2012) Cardiac sympathetic activation in patients with pulmonary arterial hypertension.. Am J Physiol Regul Integr Comp Physiol, 302 (10), pp. R1153-R1157.

Bowen TS; Cannon DT; Murgatroyd SR; Birch KM; Witte KK; Rossiter HB (2012) The intramuscular contribution to the slow oxygen uptake kinetics during exercise in chronic heart failure is related to the severity of the condition. JOURNAL OF APPLIED PHYSIOLOGY, 112 , pp. 378-387.

Al-Najjar Y; Witte KK; Clark AL (2012) Chronotropic incompetence and survival in chronic heart failure. International Journal of Cardiology, 157 (1), pp. 48-52.

Motwani M; Witte KK; Plein S; Greenwood JP (2011) Isolated Left Ventricular Apical Hypoplasia Evaluated by Cardiovascular Magnetic Resonance and Gadolinium Enhancement Techniques. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 58 , pp. 2355-2355.

Bogale N; Witte K; Priori S; Cleland J; Auricchio A; Gadler F; Gitt A; Limbourg T; Linde C; Dickstein K; Investigators NC (2011) The European Cardiac Resynchronization Therapy Survey: comparison of outcomes between de novo cardiac resynchronization therapy implantations and upgrades. EUROPEAN JOURNAL OF HEART FAILURE, 13 , pp. 974-983.

Cubbon RM; Gale CP; Kearney LC; Schechter CB; Brooksby WP; Nolan J; Fox KAA; Rajwani A; Baig W; Groves D; Barlow P; Fisher AC; Batin PD; Kahn MB; Zaman AG; Shah AM; Byrne JA; Lindsay SJ; Sapsford RJ; Wheatcroft SB; Witte KK; Kearney MT (2011) Changing Characteristics and Mode of Death Associated With Chronic Heart Failure Caused by Left Ventricular Systolic Dysfunction A Study Across Therapeutic Eras. CIRCULATION-HEART FAILURE, 4 .

Witte KK; Clark AL (2011) NYHA class I heart failure is not 'mild'. INTERNATIONAL JOURNAL OF CARDIOLOGY, 146 , pp. 128-129.

Begg GA; Witte KKA (2010) Closing the Door After the Horse has Bolted: Device Therapy in Patients With End-Stage Heart Failure. JOURNAL OF CARDIAC FAILURE, 16 , pp. 938-939.

Cubbon RM; Gale CP; Kearney LC; Brooksby P; Nolan J; Fox KA; Rajwani A; Baig W; Batin PD; Kahn MB; Zaman AG; Shah A; Lindsay S; Sapsford RJ; Wheatcroft SB; Witte KK; Kearney MT (2010) Changing Characteristics and Outcomes of Patients with Chronic Heart Failure due to Left Ventricular Systolic Dysfunction: a Study Across Therapeutic Eras. CIRCULATION, 122 .

Cleland JGF; Witte K (2010) Calcium and heart attacks Reply. BRITISH MEDICAL JOURNAL, 341 .

Shelton RJ; Ingle L; Rigby AS; Witte KK; Cleland JGF; Clark AL (2010) Cardiac output does not limit submaximal exercise capacity in patients with chronic heart failure. EUROPEAN JOURNAL OF HEART FAILURE, 12 , pp. 983-989.

Begg GA; Cleland JGF; Witte KKA (2010) Letter by Begg et al Regarding Article, "The Effects of Vitamin D Supplementation on Physical Function and Quality of Life in Older Heart Failure Patients: A Randomized Controlled Trial". CIRCULATION-HEART FAILURE, 3 , pp. E24-E24.

McKenna C; Burch J; Suekarran S; Walker S; Bakhai A; Witte K; Harden M; Wright K; Woolacott N; Lorgelly P; Fenwick L; Palmer S (2010) A systematic review and economic evaluation of the clinical effectiveness and cost-effectiveness of aldosterone antagonists for postmyocardial infarction heart failure. HEALTH TECHNOLOGY ASSESSMENT, 14 , pp. 1-+.

Cleland JG; Witte K; Steel S (2010) Calcium supplements in people with osteoporosis.. BMJ (Clinical research ed.), 341 .

Cleland JGF; Witte K (2010) Calcium and heart attacks: Editorialists' reply. BMJ (Online), 341 (7773), pp. 569-569.

Cleland JGF; Witte K; Steel S (2010) Calcium supplements in people with osteoporosis. BMJ (Online), 341 (7767), pp. 260-260.

Al-Najjar Y; Witte KK; Clark AL (2010) Chronotropic incompetence and survival in chronic heart failure. International Journal of Cardiology, .

McKenna C; Burch J; Suekarran S; Walker S; Bakhai A; Witte K; Harden M; Wright K; Woolacott N; Lorgelly P; Fenwick L; Palmer S (2010) A systematic review and economic evaluation of the clinical effectiveness and cost-effectiveness of aldosterone antagonists for postmyocardial infarction heart failure. Health Technology Assessment, 14 (24), pp. i-161.

Witte KK; Clark AL (2009) Chronotropic incompetence does not contribute to submaximal exercise limitation in patients with chronic heart failure. INTERNATIONAL JOURNAL OF CARDIOLOGY, 134 , pp. 342-344.

Cubbon RM; Witte KKA (2009) Cardiac resynchronisation therapy for chronic heart failure and conduction delay. BRITISH MEDICAL JOURNAL, 338 .

Carasso S; Rakowski H; Witte KK; Smith P; Carasso D; Garceau P; Sasson Z; Parker JD (2009) Left Ventricular Strain Patterns in Dilated Cardiomyopathy Predict Response to Cardiac Resynchronization Therapy: Timing Is Not Everything. JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 22 , pp. 242-250.

Witte KKA; Clark AL (2009) Marine polyunsaturated fatty acids in heart failure are the theoretical benefits matched by the clinical data?. Polskie Archiwum Medycyny Wewnetrznej, 119 (3), pp. 162-169.

Cubbon RM; Witte KKA (2009) Cardiac resynchronisation therapy for chronic heart failure. BMJ (Online), 338 (7702), pp. 1064-1069.

Witte KKA; Clark AL (2008) Dyspnoea versus fatigue: Additional prognostic information from symptoms in chronic heart failure?. EUROPEAN JOURNAL OF HEART FAILURE, 10 , pp. 1224-1228.

Witte KKA; Ford SJ; Preston T; Parker JD; Clark AL (2008) Fibrinogen synthesis is increased in cachectic patients with chronic heart failure. INTERNATIONAL JOURNAL OF CARDIOLOGY, 129 , pp. 363-367.

Witte KK; Pepper CB; Cowan JC; Thomson JD; English KM; Blackburn ME (2008) Implantable cardioverter-defibrillator therapy in adult patients with tetralogy of Fallot. EUROPACE, 10 , pp. 926-930.

Witte KK; Sasson Z; Persaud JA; Jolliffe R; Wald RW; Parker JD (2008) Biventricular pacing: Impact on exercise-induced increases in mitral insufficiency in patients with chronic heart failure. CANADIAN JOURNAL OF CARDIOLOGY, 24 , pp. 379-384.

Witte KK; Notarius CF; Ivanov J; Floras JS (2008) Muscle sympathetic nerve activity and ventilation during exercise in subjects with and without chronic heart failure. CANADIAN JOURNAL OF CARDIOLOGY, 24 , pp. 275-278.

Ingle L; Witte KK; Cleland JGF; Clark AL (2008) Combining the ventilatory response to exercise and peak oxygen consumption is no better than peak oxygen consumption alone in predicting mortality in chronic heart failure. EUROPEAN JOURNAL OF HEART FAILURE, 10 , pp. 85-88.

Witte KKA; Clark AL (2008) Carvedilol in the treatment of elderly patients with chronic heart failure. CLINICAL INTERVENTIONS IN AGING, 3 , pp. 55-70.

Witte K (2008) Subclavian access without subclavian puncture[1]. PACE - Pacing and Clinical Electrophysiology, 31 (7), pp. 925-926.

Witte KK; Clark AL (2008) GPs have pivotal role in managing CHF. Practitioner, 252 (1707), pp. 29-39.

Witte KK; Levy WC; Lindsay KA; Clark AL (2007) Biomechanical efficiency is impaired in patients with chronic heart failure. EUROPEAN JOURNAL OF HEART FAILURE, 9 , pp. 834-838.

Cleland JGF; Coletta AP; Abdellah AT; Witte KK; Hobson N; Clark AL (2007) Clinical trials update from heart rhythm 2007 and heart failure 2007: CARISMA, PREPARE, DAVID II, SAVE-PACE, PROTECT and AREA-IN-CHF. EUROPEAN JOURNAL OF HEART FAILURE, 9 , pp. 850-853.

de Silva R; Loh H; Rigby AS; Nikitin NP; Witte KKA; Goode K; Bhandari S; Nicholson A; Clark AL; Cleland JGF (2007) Epidemiology, associated factors, and prognostic outcomes of renal artery stenosis in chronic heart failure assessed by magnetic resonance angiography. AMERICAN JOURNAL OF CARDIOLOGY, 100 , pp. 273-279.

de Silva R; Nikitin NP; Witte KKA; Rigby AS; Loh H; Nicholson A; Bhandari S; Clark AL; Cleland JGF (2007) Effects of applying a standardised management algorithm for moderate to severe renal dysfunction in patients with chronic stable heart failure. EUROPEAN JOURNAL OF HEART FAILURE, 9 , pp. 415-423.

Witte KK; Parker JD (2007) Biventricular pacing in patients with right ventricular pacing-induced heart failure. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 18 , pp. E12-E12.

Witte KK; Parker JD (2007) To the editor. Journal of Cardiovascular Electrophysiology, 18 (2).

Witte KK; Clark AL (2007) Why does chronic heart failure cause breathlessness and fatigue?. PROGRESS IN CARDIOVASCULAR DISEASES, 49 , pp. 366-384.

Cleland JGF; Coletta A; Witte K (2006) Practical applications of intravenous diuretic therapy in decompensated heart failure. AMERICAN JOURNAL OF MEDICINE, 119 , pp. 26-36.

Thackray SDR; Ghosh JM; Wright GA; Witte KKA; Nikitin NP; Kaye GC; Clark AL; Tweddel A; Cleland JGF (2006) The effect of altering heart rate on ventricular function in patients with heart failure treated with beta-blockers. AMERICAN HEART JOURNAL, 152 .

Witte KKA; Nikitin NP; Cleland JGF; Clark AL (2006) Excessive breathlessness in patients with diastolic heart failure. HEART, 92 , pp. 1425-1429.

Witte KK; Clark AL (2006) Resting left ventricular function, however measured, is poorly related to exercise capacity in chronic heart failure. AMERICAN JOURNAL OF CARDIOLOGY, 98 , pp. 709-710.

Thackray SDR; Wright GA; Witte KKA; Nikitin NP; Tweddel AC; Clark AL; Cleland JGF (2006) The effect of ventricular pacing on measurements of left ventricular function: A comparison between echocardiographic methods and with radionuclide ventriculography. EUROPEAN JOURNAL OF ECHOCARDIOGRAPHY, 7 , pp. 284-292.

de Silva R; Rigby AS; Witte KKA; Nikitin NP; Tin L; Goode K; Bhandari S; Clark AL; Cleland JGF (2006) Anemia, renal dysfunction, and their interaction in patients with chronic heart failure. AMERICAN JOURNAL OF CARDIOLOGY, 98 , pp. 391-398.

Witte KK; Parker JD (2006) Identification of lateral cardiac veins for cardiac resynchronization therapy. EUROPACE, 8 , pp. 506-507.

Witte KKA; Cleland JGF; Clark AL (2006) Chronic heart failure, chronotropic incompetence, and the effects of beta blockade. HEART, 92 , pp. 481-486.

Witte KKA; Pipes RR; Nanthakumar K; Parker JD (2006) Biventricular pacemaker upgrade in previously paced heart failure patients - Improvements in ventricular dyssynchrony. JOURNAL OF CARDIAC FAILURE, 12 , pp. 199-204.

Nikitin NP; Loh PH; de Silva R; Witte KKA; Lukaschuk EI; Parker A; Farnsworth TA; Alamgir FM; Clark AL; Cleland JGF (2006) Left ventricular morphology, global and longitudinal function in normal older individuals: A cardiac magnetic resonance study. INTERNATIONAL JOURNAL OF CARDIOLOGY, 108 , pp. 76-83.

Witte KK; Clark AL (2006) Micronutrients and their supplementation in chronic cardiac failure. An update beyond theoretical perspectives. HEART FAILURE REVIEWS, 11 , pp. 65-74.

de Silva R; Nikitin NP; Witte KKA; Rigby AS; Goode K; Bhandari S; Clark AL; Cleland JGF (2006) Incidence of renal dysfunction over 6 months in patients with chronic heart failure due to left ventricular systolic dysfunction: contributing factors and relationship to prognosis. EUROPEAN HEART JOURNAL, 27 , pp. 569-581.

Thackray SDR; Witte K; Ghosh J; Nikitin N; Anderson A; Rigby A; Goode K; Clark AL; Cleland JGF (2006) N-terminal brain natriuretic peptide as a screening tool for heart failure in the pacemaker population. EUROPEAN HEART JOURNAL, 27 , pp. 447-453.

Witte KK; Clark AL (2006) Heart failure improvement from a supplement containing copper: reply. EUROPEAN HEART JOURNAL, 27 , pp. 117-118.

Witte KK; Clark AL (2006) Chronotropic Incompetence in Heart Failure. Journal of the American College of Cardiology, 48 (3), pp. 595-595.

Klevay LM; Witte KK; Clark AL (2006) Heart failure improvement from a supplement containing copper [2] (multiple letters). European Heart Journal, 27 (1), pp. 117-118.

De Silva R; Nikitin NP; Witte KKA; Rigby AS; Goode K; Bhandari S; Clark AL; Cleland JGF (2006) Incidence of renal dysfunction over 6 months in patients with chronic heart failure due to left ventricular systolic dysfunction: Contributing factors and relationship to prognosis. European Heart Journal, 27 (5), pp. 569-581.

Witte KKA; Nikitin NP; Parker AC; von Haehling S; Volk HD; Anker SD; Clark AL; Cleland JGF (2005) The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure. EUROPEAN HEART JOURNAL, 26 , pp. 2238-2244.

Cleland JGF; Coletta AP; Lammiman M; Witte KK; Loh H; Nasir M; Clark AL (2005) Clinical trials update from the European Society of Cardiology Meeting 2005: CARE-HF extension study, ESSENTIAL, CIBIS-III, S-ICD, ISSUE-2. STRIDE-2, SOFA, IMAGINE, PREAMI, SIRfUS-II and ACTIVE. EUROPEAN JOURNAL OF HEART FAILURE, 7 , pp. 1070-1075.

Witte KKA; Thackray SDR; Lindsay KA; Cleland JGF; Clark AL (2005) Metabolic gas kinetics depend upon the level of exercise perfonned. EUROPEAN JOURNAL OF HEART FAILURE, 7 , pp. 991-996.

Nikitin NP; Witte KKA; Ingle L; Clark AL; Farnsworth TA; Cleland JGF (2005) Longitudinal myocardial dysfunction in healthy older subjects as a manifestation of cardiac ageing. AGE AND AGEING, 34 , pp. 343-349.

Witte KKA; Kelly SJ; Parker JD; Nanthakumar K (2005) Deployment of left ventricular lead from the ipsilateral side of central vein obstruction. JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY, 13 , pp. 47-50.

Witte KKA; Thackray S; Nikitin NP; Cleland JGF; Clark AL (2005) The effects of long-term beta-blockade on the ventilatory responses to exercise in chronic heart failure. EUROPEAN JOURNAL OF HEART FAILURE, 7 , pp. 612-617.

Olsson LG; Swedberg K; Clark AL; Witte KK; Cleland JGF (2005) Six minute corridor walk test as an outcome measure for the assessment of treatment in randomized, blinded intervention trials of chronic heart failure: a systematic review. EUROPEAN HEART JOURNAL, 26 , pp. 778-793.

Witte KKA; Clark AL (2005) beta-blockers and inspiratory pulmonary function in chronic heart failure. JOURNAL OF CARDIAC FAILURE, 11 , pp. 112-116.

Witte KKA; Clark AL (2005) Cycle exercise causes a lower ventilatory response to exercise in chronic heart failure. HEART, 91 , pp. 225-226.

Witte KKA; Clark AL (2005) Progress in cardiology in northern England?. British Journal of Cardiology, 12 (6), pp. 441-441.

Witte KKA; Clark AL (2005) β-blockers and inspiratory pulmonary function in chronic heart failure. Journal of Cardiac Failure, 11 (2), pp. 112-116.

Witte KK; Clark AL (2005) Chronic heart failure and multiple micronutrient supplementation: realistic hope or idealistic conjecture?. Heart failure monitor., 4 (4), pp. 123-129.

Witte KKA; Nikitin NP; De Silva R; Cleland JGF; Clark AL (2004) Exercise capacity and cardiac function assessed by tissue Doppler imaging in chronic heart failure. HEART, 90 , pp. 1144-1150.

Witte KKA; Clark AL (2004) The effect of aspirin on the ventilatory response to exercise in chronic heart failure. EUROPEAN JOURNAL OF HEART FAILURE, 6 , pp. 745-748.

Witte KKA; Desilva R; Chattopadhyay S; Ghosh J; Cleland JGF; Clark AL (2004) Are hematinic deficiencies the cause of anemia in chronic heart failure?. AMERICAN HEART JOURNAL, 147 , pp. 924-930.

Witte KKA; Morice A; Cleland JGF; Clark AL (2004) The reversibility of increased airways resistance in chronic heart failure measured by impulse oscillometry. JOURNAL OF CARDIAC FAILURE, 10 , pp. 149-154.

Witte KKA; Clark AL (2004) The effect of aspirin on the ventilatory response to exercise in chronic heart failure. European Journal of Heart Failure, 6 (6), pp. 745-748.

Nikitin NP; Witte KKA (2004) Application of tissue Doppler imaging in cardiology. CARDIOLOGY, 101 , pp. 170-184.

Witte KKA; Thackray SDR; Nikitin NP; Cleland JGF; Clark AL (2003) The effects of alpha and beta blockade on ventilatory responses to exercise in chronic heart failure. HEART, 89 , pp. 1169-1173.

Thackray SDR; Witte KKA; Nikitin NP; Clark AL; Kaye GC; Cleland JGF (2003) The prevalence of heart failure and asymptomatic left ventricular systolic dysfunction in a typical regional pacemaker population. EUROPEAN HEART JOURNAL, 24 , pp. 1143-1152.

Witte KKA; Thackray SDR; Nikitin NP; Cleland JGF; Clark AL (2003) Pattern of ventilation during exercise in chronic heart failure. HEART, 89 , pp. 610-614.

Nikitin NP; Witte KKA; Thackray SDR; Goodge LJ; Clark AL; Cleland JGF (2003) Effect of age and sex on left atrial morphology and function. European Journal of Echocardiography, 4 (1), pp. 36-42.

Nikitin NP; Witte KKA; Thackray SDR; De Silva R; Clark AL; Cleland JGF (2003) Longitudinal Ventricular Function: Normal Values of Atrioventricular Annular and Myocardial Velocities Measured with Quantitative Two-dimensional Color Doppler Tissue Imaging. Journal of the American Society of Echocardiography, 16 (9), pp. 906-921.

Nikitin NP; Witte KKA; Clark AL; Cleland JGF (2002) Color tissue Doppler-derived long-axis left ventricular function in heart failure with preserved global systolic function. AMERICAN JOURNAL OF CARDIOLOGY, 90 , pp. 1174-+.

Witte KKA; Clark AL (2002) Nutritional abnormalities contributing to cachexia in chronic illness. INTERNATIONAL JOURNAL OF CARDIOLOGY, 85 , pp. 23-31.

Witte KKA; Morice A; Clark AL; Cleland JGF (2002) Airway resistance in chronic heart failure measured by impulse oscillometry. JOURNAL OF CARDIAC FAILURE, 8 , pp. 225-231.

Witte KKA; Clark AL (2002) Is the elevated slope relating ventilation to carbon dioxide production in chronic heart failure a consequence of slow metabolic gas kinetics?. EUROPEAN JOURNAL OF HEART FAILURE, 4 , pp. 469-472.

Thackray SD; Witte KK; Nikitin NP; Cleland JG (2002) The prevalence of heart failure in the permanently paced population and the utility of BNP as a screening tool. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 39 , pp. 160A-160A.

Nikitin NP; Witte KK; Thackray SD; Alamgir MF; Goodge LJ; Clark AL; Cleland JG (2002) Functional mitral regurgitation in patients with chronic heart failure: Relationship to left ventricular and left atrial structural and functional parameters. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 39 , pp. 130A-130A.

Nikitin NP; Witte KK; Thackray SD; Cleland JG; Clark AL (2001) Right ventricular function is an important determinant of exercise capacity in patients with chronic heart failure. CIRCULATION, 104 , pp. 553-554.

Nikitin NP; Thackray SDR; Witte KKA; Anderson A; Clark AL; Cooklin MC; Cleland JGF (2001) Screening for heart failure in the permanently paced population. EUROPEAN HEART JOURNAL, 22 , pp. 303-303.

Nikitin NP; Witte KKA; Thackray SDR; Crabbe S; Jones P; Ford S; Clark AL; Cleland JGF (2001) Can colour-coded tissue Doppler imaging differentiate between impaired ventricular relaxation associated with ageing and that related to chronic heart failure?. EUROPEAN HEART JOURNAL, 22 , pp. 594-594.

Witte KKA; Clark AL; Cleland JGF (2001) Chronic heart failure and micronutrients. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 37 , pp. 1765-1774.

Thackray SDR; Witte KKA; Khand A; Dunn A; Clark AL; Cleland JGF (2001) Clinical trials update: highlights of the scientific sessions of the American heart association year 2000: Val HeFT, COPERNICUS, MERIT, CIBIS-II, BEST, AMIOVIRT, V-MAC, BREATHE, HEAT, MIRACL, FLORIDA, VIVA and the first human cardiac skeletal muscle myoblast transfer for heart failure. EUROPEAN JOURNAL OF HEART FAILURE, 3 , pp. 117-124.

Thackray SDR; Witte KKA; Clark AL (2001) Heart failure - A weighty problem indeed!. British Journal of Cardiology, 8 (7).

Witte K; Thackray S; Clark AL; Cooklin M; Cleland JGF (2000) Clinical trials update: IMPROVEMENT-HF, COPERNICUS, MUSTIC, ASPECT-II, APRICOT and HEART. EUROPEAN JOURNAL OF HEART FAILURE, 2 , pp. 455-460.

Witte K (2000) The HEART FAILURE Journal Club: A review of publications on heart failure in HEART. EUROPEAN JOURNAL OF HEART FAILURE, 2 , pp. 213-222.

Thackray S; Witte K; Clark AL; Cleland JGF (2000) Clinical trials update: OPTIME-CHF, PRAISE-2, ALL-HAT. EUROPEAN JOURNAL OF HEART FAILURE, 2 , pp. 209-212.

Witte K; Thackray S; Banerjee T; Clark AL; Cleland JGF (2000) Update of ELITE-II, BEST, CHAMP, and IMPRESS clinical trials in heart failure. EUROPEAN JOURNAL OF HEART FAILURE, 2 , pp. 107-112.