By 1860 the school had 60 enrolled students, requiring more space. A new site on Park Street opened in October 1865, near the Infirmary’s new site. Purpose built by George Corson, the new building could hold an annual intake of 40 students, but students would have to travel to London to take exams set by the Royal Colleges of Physicians and of Surgeons. Teaching was primarily done at the School but could take place out of the city, such as at the West Riding Lunatic Asylum in Wakefield.
The President of the new School, Mr Samuel Hay, was the grandson of LGI founder William Hey I. Other notable staff members of this era included Dr (later Sir) Clifford Allbutt, Dr Crichton Browne, Dr John Deakin Heaton and Dr Thomas Scattergood. Dr Heaton was a driving force behind the development of the Yorkshire College, the forerunner of the current University. The School merged with the College in 1884, allowing it to meet the non-compulsory curricular requirements of the Medical Act of 1858.
In 1887, the Yorkshire College, of which the School of Medicine was then part, was assimilated into The Victoria University of Manchester, though students were still examined by the Royal Colleges.

