Our research themes

We are focusing our research in mechanobiology and mechanotechnology on two key themes.

Underpinning these themes are clinically driven aims of tackling major global diseases, including:

  • musculoskeletal disease
  • heart disease
  • colorectal disease
  • liver disease
  • placental disease

Research themes

Fundamental biology

Fundamental understanding of the interactions between mechanical forces and biology and translation based on such understanding.

Our research focuses on:

  • Structural biology of force sensing
  • Protein complexes and signalling pathways of force sensing
  • Force sensing in tissue mineralization and stiffness
  • Physical exercise


Development and application of mechanotechnologies and biomechanical engineering to medical problems.

Our research focuses on:

  • Force in engineered tissue scaffolds
  • Measurement of cell stiffness, flow responses and surface effects
  • Self-assembled peptides and stiffness in tissue mineralization
  • Modulation of mechanobiology (eg small-molecules and ultrasound)
  • Tissue structure artificial intelligence